Nathan Karns (1-1, 4.58 ERA) and Joe Kelly (1-0, 2.13 ERA) are on the hill in the second of a three-game series between the Tampa Bay Rays (6-8) and the Boston Red Sox (9-5) at Tropicana Field. The Red Sox won the last game 1-0 and Boston leads the series 1-0. Action begins at 7:10 p.m. ET on Wednesday, Apr. 22 and can be seen on NESN and SunSports.

Karns pitched 5.0 innings in his last outing, surrendering two runs, striking out seven and walking four in a 5-4 defeat to the Yankees. Kelly went 5.2 innings, surrendering two runs, striking out three and walking two in a 3-2 defeat to the Orioles in his most recent start. Hanley Ramirez (.269, 9 Rs, 5 HRs, 12 RBIs, 1 SB) has been successful at the plate, going 2 for 4 yesterday with one stolen base.

Boston is a slim -112 favorite over Tampa Bay. According to the oddsmakers, the Over/Under (O/U) is currently eight runs. The Rays have an overall money line of -56 and a record as the underdog of 5-4. Within its division, Tampa Bay has a 1-3 as the underdog and a 4-6 SU. The Rays have seen a decline in scoring against teams inside their division, averaging 3.2 runs per game. They average 3.9 runs per game on the season. Tampa Bay is one of the best in the MLB in terms of steals, swiping 13 bases.

In games where it is the favorite, Boston has a 5-4 record and an overall money line of +173. They are 2-2 as the favorite against fellow AL East members, and 4-3 SU. Offensively, they average 5.4 runs per game, which is good for second in the AL. Boston is excellent at drawing walks with an AL-best 4.7 per game. The Red Sox have established a reputation of overwhelming hitters with an AL-best 8.6 strikeouts per game, making them one of the top five teams in the league.

The Red Sox have the edge in the season series, 1-0. The Rays have a 5-5 record against right-handed starting pitchers on the year, which is what they'll be facing when Kelly takes the mound. Karns (RHP) will be on the hill against the Red Sox, who have a 6-4 record against right-handed starting pitchers.

Predictions: SU Winner - BOS, O/U - Over


The Red Sox sit at 5-3 against the division, while the Rays are 4-7

Boston earned its second shutout of the season in its last game. Tampa Bay has been shut out two times this season.

When the Red Sox play into extra innings, they have a 1-0 record. The Rays are 0-1 when their games exceed nine innings.

Having scored one run in their last game, the Red Sox are going to have to up their game if they want to win this matchup. The Rays have a 3-1 record in games where opponents scored that many runs or fewer.

When they are outhit, the Rays are 1-6. The Red Sox have a 1-5 record when opponents outhit them.

Both Tampa Bay and Boston are tied at 11th in home runs, hitting 13 this season.

Ranking 10th, Tampa Bay is in the top 10 of the league in hits, notching 7.46 per game. Boston ranks in the top five at fifth with 8.54.

Tampa Bay and Boston both rank in the bottom half of the league for their on-base plus slugging percentage. Tampa Bay sits at 17th with an OPS of .681 and Boston ranks 16th with an OPS of .682.

The Red Sox are 4-5 in games where they allow one or more home runs. The Rays are 1-5 when they allow at least one homer.