Andrew Cashner (1-3, 2.62 ERA) and the San Diego Padres (11-11) square off against Dallas Keuchel (2-0, 0.62 ERA) and the Houston Astros (13-7) in a game that has the potential to be low scoring. This is the last of a three-game series at Petco Park. The Astros won the last game 14-3, continuing a five-game winning streak. Action begins at 3:40 p.m. ET on Wednesday, Apr. 29 and can be seen on ROOT-SW and FSN-SD.

Cashner is 2-1 with a 4.60 ERA in his appearances against the Astros, but goes up against a below-average Houston offense which is batting just .239 this season. Yangervis Solarte (.346, 5 Rs, 2 HRs, 12 RBIs) had another good game yesterday, going 2 for 2 with one RBI. Against the Padres, Keuchel is 0-0 with a 1.50 ERA, 1.33 WHIP, and three strikeouts. Jake Marisnick (.380, 10 Rs, 2 HRs, 9 RBIs, 6 SBs) has been successful at the plate to the start the season for the Astros, going 2 for 3 yesterday with one RBI.

San Diego is a -122 favorite against Houston and the Over/Under (O/U) for this game is sitting at six runs. The Padres have recorded an overall money line of +76 and have shown high-level performance as a favorite this season with a record of 6-3. In interleague play, they are winless both as the favorite (0-1), and SU (0-1). The Padres have seen a decline in scoring against teams in the AL, averaging 4.0 runs per game. They average 4.8 runs per game on the season. The Padres are one of the best in the MLB in terms of extra base hits with 71. San Diego's pitchers fall apart when American League teams are on the field. Its average runs allowed per game rises to 9.0 against AL teams, compared to its 4.1 season average. Opponents have consistently been struck out by the Padres, who rank fourth in the NL in strikeouts per game with 8.6.

As for their opponent, Houston is coming in with an overall money line of +675 and an impressive record of 8-4 as the dog. They played solid baseball as the underdog over their last 10 games with a 7-2 record, and an 8-2 record SU. Offensively, they average six runs per game on the road, which is the best in the AL. The Astros are an excellent base-stealing team with an MLB-best 26 stolen bases. When it comes to preventing batters from getting on base, the Astros are the best in the league with a WHIP of 1.08 for the season.

The Astros have the edge in the season series, 2-0. Cashner (RHP) will be on the hill against the Astros, who have a 7-5 record against right-handed starting pitchers.

Predictions: SU Winner - HOU, O/U - Over


Houston is 5-0 SU in its last 5 games.

The total has gone OVER in 5 of Houston's last 5 games.

The total has gone OVER in 5 of Houston's last 5 games on the road.

Houston is 5-0 SU in its last 5 games on the road.

The total has gone OVER in 4 of Houston's last 5 games when playing San Diego.

The total has gone OVER in 4 of Houston's last 5 games when playing on the road against San Diego.

In their last game, the Astros won by a margin of 11 runs. The Padres are 1-1 in games decided by a margin of 10 runs or more. The Astros have a 1-0 record in blowouts.

When the Astros play into extra innings, they have a 2-0 record. The Padres are 0-2 when their games exceed nine innings.

The Astros are coming into this game after allowing two walks during their last outing. The Padres have a 7-7 record when opponents give up that many walks or fewer.

When they are outhit, the Padres are 0-9. The Astros have a 2-3 record when opponents outhit them.

Houston tops the league in home runs with 28 this season. San Diego ranks in the top 10 at ninth with 23.

Ranking eighth, Houston is in the top 10 of the league in hits, notching 8.30 per game. San Diego ranks in the top five at second with 9.23.

San Diego and Houston both rank in the top 10 of the league for their on-base plus slugging percentage. San Diego sits at eighth with an OPS of .737 and Houston ranks ninth with an OPS of .736.

The Astros are 3-5 when they allow at least one home run. The Padres perform similarly when they allow one or more homers with a 6-9 record.