One of 15 MLB games scheduled for Wednesday, September 21 is a must-win for the home team, so make sure you read the best Tigers vs. Orioles betting pick and odds.

Detroit and Baltimore will play the third of a three-game series at Oriole Park at Camden Yards, and the Orioles are -165 moneyline favorites on BetDSI Sportsbook, while the total is set at 8.5 runs. These AL rivals have met three times this year before this series, and the Tigers won all three. Detroit also won Game 1 of the current series, while Game 2 will be played on Tuesday night.

Tigers dismantled the Orioles in the opener

The Detroit Tigers lost the series to the Houston Astros and Chicago White Sox, but they erupted for an 11-0 victory over the Baltimore Orioles in the opening game of this series. Detroit, who has the second-worst record in the American League, registered 14 hits opposite Baltimore’s two, and interestingly, the visitors didn’t hit a single homer.

Riley Greene and Ryan Kreidler led the Tigers offensively with three RBIs apiece, while Spencer Torkelson and Miguel Cabrera combined for five hits. Tyler Alexander improved to a 4-10 record after pitching for seven scoreless innings with four strikeouts and two walks.

Matt Manning (2-2) is getting his 12th start of the year when he faces the Orioles on Wednesday. The 24-year-old right-hander has a rock-solid 3.28 ERA, 1.13 WHIP, and 44/14 K/BB ratio in 57.2 innings.

Orioles disappointed in the opener against Detroit

The Baltimore Orioles, who are fighting for a wildcard spot in the AL, were blown away by the Detroit Tigers at home, and now they must find a way to bounce back and return to winning ways before it’s too late. It was already the third time Baltimore failed to score a single run this month, and they cannot afford that to happen again if they want to play in the postseason.

Ryan Mountcastle and Anthony Santander were the only Orioles who managed to hit the ball in an 11-0 loss. Tyler Wells (7-7) took a loss after surrendering five runs on four hits with three strikeouts and three walks across 3.0 innings.

Jordan Lyles (10-11) will take the mound for the 30th time this year when he meets Detroit on Wednesday. The 31-year-old right-hander owns a 4.70 ERA, 1.45 WHIP, and 129/50 K/BB ratio over 161.0 innings of work.



  • 4-1 in the last five games vs. a starter with a WHIP greater than 1.30
  • 4-1 in the last five road games


  • 1-4 in the last five home games
  • 2-5 in the last seven home games vs. a right-handed starter

Detroit Tigers vs. Baltimore Orioles Pick

With the exception of Game 2 of the series, which will be played on Tuesday night and we don’t know the outcome, Detroit won all games against Baltimore this season, which is rather shocking given how the Orioles are playing this year. Jordan Lyles is struggling right now; he surrendered 12 runs in his last two starts and is experiencing the worst month of the campaign, while Matt Manning is having the best month of the season and he didn’t allow more than two runs per game in September. Even if Baltimore gets a win here, I don’t think it will be an easy one.

Pick: Take the Tigers at +4.5 Run Line (-130)

The Total

Even though Lyles is not playing well and Detroit scored 11 runs in Game 1, I expect to see a low-scoring affair on Wednesday. Manning is cruising right now and it’s questionable whether the Orioles can score more than two runs against him in this one. Under is 19-7-1 in the last 27 H2H meetings; Under is 5-2-1 in the previous eight H2H duels in Baltimore, while Under is 19-7 in the Orioles’ last 26 vs. American League Central opponents.

Pick: Go Under 8.5 runs (-110)