The NFL action continues with Week 7 games, and one of the conference duels will be played on Sunday, October 23, so here you can see the best Lions vs. Cowboys betting pick and odds.

Detroit will be looking to avoid the fourth consecutive defeat when they visit Dallas at AT&T Stadium. The Cowboys are -6.5 favorites on MyBookie Sportsbook, while the total is set at 49 points. These conference rivals haven’t met since 2019.

Lions were kept off the scoreboard by the Patriots in a big loss

The Detroit Lions (1-4, 3-2 ATS) did lose their third game in a loss, but scoring zero points against the New England Patriots came as a surprise. Especially after scoring 45 against Seattle and at least 25 in each of the previous games this season. Detroit wasn’t bad against New England but did commit a pair of turnovers, one of which turned out to be crucial as the Pats returned a fumble for a 59-year TD. In the end, New England won 29-0.

Jared Goff completed 19 of 35 passes for 229 yards and an interception. Josh Reynolds and Craig Reynolds combined for 160 receiving yards on nine catches (12 targets). Jamaal Williams had 56 yards on the ground on 15 carries. Defensively, DeShon Elliott was strong with game-high 12 tackles (three for a loss).  

WR DJ Chark Jr. (ankle) and DE Charles Harris (groin) are out and will not be able to face the Cowboys on Sunday. RB D’Andre Swift (ankle) is questionable to play.

Cowboys’ four-game winning run snapped in Philadelphia

The Dallas Cowboys (4-2, 4-2 ATS) were on a four-game winning streak, but couldn’t make it five in a row when they faced the divisional foes and the only unbeaten team in the NFL – the Philadelphia Eagles. Following a scoreless opening quarter, the Eagles got to a 20-0 lead in the second and controlled the tilt to secure a 26-17 victory. The fact that Dallas committed three turnovers and forced one on the other hand certainly didn’t help the Cowboys.

Cooper Rush completed 18 of 38 passes for 181 yards, one touchdown, and three interceptions. Jake Ferguson caught that lone TD pass from Rush, while CeeDee Lamb led the team with 68 receiving yards on five receptions. Ezekiel Elliott did well on the ground and posted 81 yards with a touchdown on 13 carries. Dallas had four sacks opposite Philadelphia’s zero, and Malik Hooker led the team with 13 tackles.



  • 1-4 ATS in the last five games played in October


  • 20-8 ATS in the last 28 games overall
  • 6-1 ATS in the last seven games following an ATS loss
  • 16-5 ATS in the last 21 vs. NFC rivals

Detroit Lions and Dallas Cowboys Pick  

Dallas will be stronger for Dak Prescott in this one, and despite all the expectations and projections, the Cowboys have a 4-2 record, winning four games without him under the center. Prescott will start against Detroit and the Cowboys should have an easier job on offense, given they are facing the league-worst defense that allows 34.0 points per game. On the other hand, Dallas has the third-best D in the NFL that allows 16.3 ppg, and even the Lions’ high-flying offense will find it hard to penetrate through it.

Pick: Take the Cowboys at -6.5 (-110)

The Total

Dallas allowed more than 19 points only once this season, and it was in the most recent loss to the Eagles. Detroit scored zero in its latest game, and I don’t think they will return to the form before against one of the best defensive teams in the league. The Cowboys have the ability to control much better offenses than Detroit’s, but their offense is not efficient and I don’t expect a lot of points on the other end. Under is 6-2 in the Lions’ last eight games following an ATS loss; Under is 7-3 in Detroit’s previous ten road games, Under is 5-1-1 in the Cowboys’ last seven games overall.

Pick: Go Under 50.5 points (-135)