Denver Broncos vs. Seattle Seahawks Odds, Pick, Prediction 9/12/22

The premiere Monday Night Football of the new NFL season is going to be played in Seattle, where all eyes will be on Russell Wilson, and you can’t afford to miss the best Broncos vs. Seahawks betting pick and odds.

Denver and Seattle will play their first game of the new NFL campaign when they face at Lumen Field on September 12. The Broncos are -6.5 favorites on BetOnline Sportsbook, while the total is set at 44 points. These inter-conference foes haven’t met since 2018 when the Broncos beat the Seahawks 27-24 in Week 1 in Denver.

Wilson to return to Seattle

The Denver Broncos will visit the Seattle Seahawks with their new quarterback. Imagine the coincidence that the NFL schedule-makers gave us a dramatic Russell Wilson return to the Rain City on the very first Monday night. Russell spent ten years with the Seahawks and won them their lone Super Bowl. Wilson recently penned a five-year extension worth $245 million, and he is brought to the Mile High to take the Broncos to the AFC West title and beyond.

The Broncos needed a Pro Bowl quarterback to lead them and connect with a lot of talented receivers at the skill positions such as wideouts Courtland Sutton and Jerry Jeudy. Tight end Albert Okwuegbunam and wide receiver KJ Hamler (questionable with a knee injury), who missed almost the entire last season, are also at Wilson’s disposal in the air. Javonte Williams and Melvin Gordon III will share snaps in the backfield, so Denver’s offense is looking very good.

On defense, DE Randy Gregory and LB Josey Jewell are questionable, but there is a possibility at least one of them will play on Monday in Seattle.

Seahawks named Geno Smith a starter against the Broncos

The Seattle Seahawks will enter a new era on Monday against the Denver Broncos and will have to start accustoming to life without former QB Russell Wilson. Geno Smith, who served as Wilson’s backup for the last two years, will start for the Seahawks on MNF, with an ex-Bronco Drew Lock as the No. 2 in Seattle.

Alongside Wilson, the Seahawks also lost Pro Bowl middle linebacker Bobby Wagner, who joined the reigning NFL champions Los Angeles Rams. The chances are high that Seattle will be last in the NFC West and perhaps have the No. 1 pick in next year’s draft. Even after all the off-season moves, the Seahawks still have quite talented receivers. Tyler Lockett and DK Metcalf combined for 2,000 receiving yards in each of the previous three seasons. Those numbers will likely drop this year, but these two are still lethal wideouts. Noah Fant, a former Denver tight end, is another option in the passing game, while Rashaad Penny will get most of the carries.

A promising rookie running back Kenneth Walker III will probably be out after hernia surgery last month. CB Artie Burns (groin), LB Alton Robinson (knee), and long snapper Tyler Ott (shoulder) all missed practice this week and are questionable to feature.



  • 8-2 ATS in the last ten games on fieldturf
  • 4-1-2 ATS in the last seven games in Week 1
  • 5-1 ATS in the last six games in September


  • 3-6 SU in their last nine games at home

Denver Broncos vs. Seattle Seahawks Pick  

Even if Geno Smith clicks with his receiving options, Lockett and Metcalf, before everyone, don’t expect the chemistry that Russell Wilson developed with them over the past three years. The same could be said for Wilson and his new receivers, but let’s be real, Russell is a way better QB than Geno. It’s going to be a tough night on offense for the Seahawks because Denver’s defense is too good to score many points against. I am backing Wilson to lead his side to three or four touchdowns at least and cover the spread.

Pick: Take the Broncos at -6.5 (-110)

The Total

While I don’t think Denver’s offense will have serious problems at Lumen Field, I still don’t expect Wilson and the Broncos to score 40 points against Seattle. Recent H2H duels were high-scoring, but this one doesn’t have real potential to be one. The Seahawks will be sluggish on offense, the Broncos will control the game clock, and I see Under on this clash. Under is 8-3 in the Broncos’ last 11 games overall, Under is 7-1 in Denver’s previous eight games as a road favorite, while Under is 7-2 in the Seahawks’ last nine games as an underdog.

Pick: Go Under 44.5 points (-120)