Week 6 in the NFL concludes with TNF between the divisional rivals on Monday, October 17, and here you can read the best Broncos vs. Chargers betting pick and odds.

Denver and Los Angeles will enter this tilt in different moods when they meet at Arrowhead Stadium. The Broncos lost two in a row, while the Chargers won the last two. The Chargers are -4.5 favorites on BetOnline Sportsbook, while the total is set at 45.5 points. These divisional rivals have met twice in 2021, and each team recorded a home win.

Broncos lost another game thanks to bad decisions from head coach

The Denver Broncos (2-3, 1-4 ATS) suffered the second straight defeat, but after deservedly losing to the Las Vegas Raiders in Week 4, they beat themselves in Week 5. The Broncos and Indianapolis Colts played another low-scoring affair in Denver, and the game went to overtime after the visitors tied to 9-9 with a successful FG late on. Indy took a 12-9 lead in OT, and Denver had a chance to tie with a field goal, but HC Nathaniel Hackett opted to go with 4th& 1 from the Colts’ five yards and take the win, but that didn’t pay off and the Broncos were left empty-handed.

Russell Wilson completed 21 of 39 passes for 274 yards and two interceptions. Both interceptions came deep into Indianapolis’ half, including the second one which was a bit more than two minutes to go. Courtland Sutton and Jerry Jeudy combined for 127 yards on eight receptions (19 targets). On the ground, Melvin Gordon III led the team with 54 yards on 15 carries. Defensively, Caden Sterns recorded a pair of picks, Bradley Chubb had 2.5 sacks, and Alex Singleton registered a game-high nine tackles.

DE Randy Gregory (knee), CB Ronald Darby (ACL), T Garett Bolles (leg), WR Tim Patrick (knee), CB Michael Ojemudia (elbow), and RB Javonte Williams (knee) are out. S Justin Simmons (quad) and S P.J. Locke III (concussion) are questionable to play on Monday against the Chargers.

Chargers edged the Browns on the road

The Los Angeles Chargers (3-2, 4-1 ATS) are back home after a two-game road trip on which they secured a couple of wins over the Houston Texans and Cleveland Browns. The most recent one over Cleveland came after the Chargers erased a 14-point deficit early on and won 30-28 through Taylor Bertolet’s field goal in the fourth quarter.

Justin Herbert completed 22 of 34 passes for 228 yards and a touchdown. Austin Ekeler needed just one yard to get 200 from scrimmage. He dominated on the ground with 173 yards and a TD on 16 attempts, while Ekeler also caught that lone TD pass from Herbert. Mike Williams led all the receivers with 134 yards on ten receptions. On defense, Derwin James Jr. was a monster with game-high 14 tackles.

DE Joey Bosa (groin) and WR Jalen Guyton (knee) are out and will not feature on Monday against Denver. WR Keenan Allen (hamstring) and K Dustin Hopkins (quad) are questionable.



  • 1-4 ATS in the last five games overall
  • 0-5 ATS in the last five road games
  • 1-4 ATS in the last five vs. AFC West rivals

Los Angeles:

  • 4-1 ATS in the last five games overall
  • 8-3 ATS in the last 11 vs. AFC West opponents

Denver Broncos vs. Los Angeles Chargers Pick  

Denver perhaps has one of the best defenses in the league, but its offense is criminally weak, which is shocking considering what kind of a quarterback they have under the center. Still, Russell Wilson is struggling in the opening few weeks of his first season with Denver, and although the Chargers have the third-worst D in the NFL that allows 27.2 ppg, I am backing Los Angeles’ offense to prevail here. Justin Herbert, Austin Ekeler, and Mike Williams will be too much for the Broncos to handle. Even if the visitors manage to limit the Chargers, they don’t have answers on the other end.

Pick: Take the Chargers at -4.5 (-110)

The Total

Only because of the Chargers’ bad defense and a top 10 offense that produces the second-best 291.2 passing yards per game, I will go with Over in this one. I don’t believe in Denver’s offense, but they are facing a weak defensive team, and I wouldn’t be surprised if the Broncos score 20+ here, which would be only the second time this year. Over is 4-1 in the Broncos’ last five games after scoring less than 15 points in their previous game; Over is 9-2 in the Chargers’ previous 11 games overall, while Over is 5-1 in Los Angeles’ last six home games.

Pick: Go Over 45.5 points (-110)