The Divisional Round in the NFL playoffs will conclude on Sunday, January 22, with this NFC clash in Santa Clara, and here you can take a look at the best Cowboys vs. 49ers betting pick and odds.

San Francisco is looking for the 11th consecutive win when they welcome Dallas at Levi’s Stadium. The 49ers are -3.5 favorites on BetDSI Sportsbook, while the total is set at 45.5 points. These conference rivals met in the Wild Card last year and the 49ers won 23-17 in Arlington.

Cowboys stopped Brady and the Bucs

The Dallas Cowboys (13-5-0, 10-7-1 ATS) displayed a commanding defensive performance in a 31-14 road victory over the Tampa Bay Buccaneers. It was a sweet revenge for a 19-3 Round 1 loss at home. Dallas was fantastic defensively in the first half and kept the hosts off the scoreboard, while the offense did its job and built a 24-0 lead early in the second half. The Cowboys relaxed a bit when the game was decided, but it was a fully deserved victory for Dallas.

Dak Prescott played his best game of the campaign as he completed 25 of 33 passes for 305 yards and season-high four touchdowns. He also added a rushing TD. Tony Pollard had a game-high 77 rushing yards on 15 carries, but the Cowboys were the most dangerous through the air. Dalton Schultz was impressive with a game-high 95 yards and two touchdowns on seven receptions. CeeDee Lamb and Michael Gallup combined for 114 yards and scored a TD apiece on nine catches. On defense, Leighton Vander Esch led the team with nine tackles and two defended passes.

T Jason Peters (knee) and S Jayron Kearse (knee) are questionable to play on Sunday against San Francisco.

49ers didn’t have problems with the Seahawks

The San Francisco 49ers (14-4-0, 12-6-0 ATS) had the easiest job of all favorites in the Wild Card round. They beat the Seattle Seahawks 41-23 at home despite trailing 17-16 at halftime. There was only one team in the second half; the 49ers scored 25 consecutive points before DK Metcalf scored a touchdown to soften a defeat for the Seahawks. San Francisco dominated total yards (505-332) and forced a pair of turnovers, committing none on the other end.

Brock Purdy was great in his first-ever playoff game. The rookie quarterback completed 18 of 30 passes for 332 yards and three touchdowns with one rushing TD. Deebo Samuel had a monster game in the air as he caught six passes for 133 yards and a score. Elijah Mitchell and Christian McCaffrey also scored receiving touchdowns. On the ground, CMC had a game-high 119 yards on 15 carries. Defensively, Charles Omenihu was credited with two of the team’s three sacks, while Dre Greenlaw registered a game-high 11 tackles.

QB Jimmy Garoppolo (foot), WR Jordan Matthews (knee), and QB Trey Lance (ankle) are done for the season.



  • 0-3-1 ATS in the last four games following an ATS win
  • 2-9 ATS in the last 11 games in January
  • 1-5-1 ATS in the last seven games after scoring more than 30 points in their previous game

San Francisco:

  • 22-8 ATS in the last 30 games overall
  • 12-2 ATS in the last 14 home games
  • 5-0 ATS in the last five Divisional playoffs games

Dallas Cowboys vs. San Francisco 49ers Pick

Dallas’ offense impressed against Tampa Bay, but the Cowboys will have a much harder job against the best defense in the NFL that allows 16.3 points per game. Pollard and Elliott will find it hard to move the chains on the ground as San Francisco has the second-best run defense in the league that surrenders only 77.7 yards per contest. The Cowboys’ offense is actually a bit better than San Francisco’s, but I am backing a stronger defense to prevail in this one. Also, the Niners have an offense capable of outscoring any team in the NFL and are coming off a season-high 41-point game.

Pick: Take the 49ers at -3 (-110)

The Total

I mentioned San Francisco’s league-best defense, but it’s important to note that Dallas also has a strong defense that allows 20.1 points per game – the fifth-best in the NFL. Even though both sides have prolific offenses, this game is going to be all about defense, and the stronger will get an edge. Under is 4-1 in the Cowboys’ last five road games; Under is 8-2 in the 49ers’ previous ten playoff games, while Under is 10-4 in the 49ers’ last 14 vs. a team with a winning record.

Pick: Go Under 47.5 points (-133)