<p>In Week 12 of the 2025 regular season, the Clemson Tigers will travel to face the Louisville Cardinals. The game will take place at L&amp;N Federal Credit Union Stadium in Louisville, KY. Fans can catch the action on ESPN at 7:30 PM on Friday, November 14, 2025.</p> <p>Clemson enters the game with a 4-5 record, showing a 2-1 performance on the road. Louisville holds a 7-2 record and is ranked 19th in the AP Poll. The Cardinals have been strong at home, with a 4-2 record. Both teams are part of the Atlantic Coast Conference.</p> <h2>Clemson Team Preview</h2> <p>The Clemson Tigers have had a mixed bag of results in recent games. They won against Florida State 24-10 with strong defense, forcing turnovers without giving any up. However, they faced a narrow defeat against Duke, losing 46-45 despite gaining more first downs and rushing yards.</p> <p>Clemson’s quarterback, Cade Klubnik, has played eight games, throwing for 2,136 yards and 14 touchdowns. He is ranked first on the team in passing yards and touchdowns. The team’s rushing attack is led by Adam Randall, who has rushed for 570 yards and scored six touchdowns in nine games.</p> <p>On the injury front, Clemson has several players uncertain to play due to injuries, including Armon Mason and Jay Haynes. Bryant Wesco Jr. and Easton Ware are out for the season with head and shoulder injuries, respectively. These injuries could impact the Tigers' depth and performance in upcoming games.</p> <h2>Clemson vs Louisville Game Day Info</h2> <ul><li>Sport: NCAA Football</li><li>Teams: Clemson Tigers vs. Louisville Cardinals</li><li>Venue: L&amp;N Federal Credit Union Stadium in Louisville, KY</li><li>Date: Friday, November 14, 2025</li><li>Betting Odds: Clemson +130, Louisville -155</li></ul> <h2>Louisville Team Preview</h2> <p>The Louisville Cardinals have had a mixed season so far. They have won games against Virginia Tech, Boston College, and Miami. However, they have also lost close games to California and Virginia. Their record reflects the ups and downs they have faced this season.</p> <p>The Cardinals' offense has been a key factor in their games. They have scored 296 points this season, ranking 34th. Their rushing game has been strong, with 1,404 yards, but their passing game ranks 59th with 2,219 yards. The team will look to improve their passing efficiency in upcoming games.</p> <p>On defense, the Cardinals have allowed 195 points, placing them 79th. They have been effective in getting sacks and interceptions, with 19 sacks and 12 interceptions this season. Louisville's defense will aim to keep up their pressure on opposing quarterbacks while improving on stopping the run game.</p> <h2>BTB Betting Pick</h2> <p>The current line has Louisville as a 3-point favorite against Clemson. Clemson has a strong passing offense, ranked 20th, and a solid defense with 25 sacks this season. Given these factors, Clemson covering the +3 spread looks like a good pick. The projected score is Louisville 27, Clemson 24.</p> <p>The total for the game is set at 50.5 points. Clemson's offense has scored 251 points this season, while Louisville has scored 296 points. Both teams have defenses ranked in the middle of the pack. The projected total score of 51 points suggests taking the over is a reasonable choice.</p>

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