Cincinnati takes on San Francisco in the second of a three-game series at Oracle Park, so we have prepared the best Reds vs. Giants betting pick and odds for Saturday, June 25, 2022. 

The Giants are listed as firm -220 home favorites on BetOnline Sportsbook, while the Reds sit at +220 moneyline odds with a total of 7.5 runs. Cincinnati won a three-game home series against San Francisco in May, while the opening contest of this set has been excluded from the analysis.  

The Reds hope Mike Minor will start improving                                      

The 23-46 Cincinnati Reds entered Friday’s battle at Oracle Park in San Francisco riding a seven-game losing streak. They held the worst record in the National League and the highest ERA in the majors (5.38) while scoring 4.32 runs per game (18th in the MLB). 

Mike Minor will get the starting call Saturday. In his first season with the Cincinnati Reds, the 34-year-old southpaw is sporting a 1-3 record, 6.97 ERA, 7.34 FIP, and 1.50 WHIP in four starts and 20.2 innings of work. 

Minor joined the Reds’ rotation in June and hasn’t allowed less than three earned runs in each of his four appearances. Last Sunday, the veteran lefty was charged for a loss in a 6-3 home defeat to the Milwaukee Brewers, yielding four earned runs on six hits and three free passes through six innings. 

The Giants look to get another strong outing from Logan Webb        

The 38-31 San Francisco Giants were sitting at the third spot in the NL West on Friday. They trailed the San Diego Padres by four and a half games and the Los Angeles Dodgers by five and a half games. The Jints have lost four of their previous five tilts, including three one-run defeats at the Atlanta Braves. 

Logan Webb will toe the slab Saturday, and the 25-year-old right-hander holds a strong 6-2 record, 3.26 ERA, 3.06 FIP, 1.16 WHIP, and 75/20 K/BB ratio in 14 starts (85.2 innings) in 2022. He’s had ups and downs, but Webb has been outstanding over his previous three starts, tallying a 1.37 ERA and 2.47 FIP across 19.2 frames of work. 

Last Monday, Logan pitched seven innings of a one-run ball against the Braves. He whiffed seven and surrendered six hits to the reigning champs. Webb is 4-1 with a sharp 2.74 ERA and 38/9 K/BB ratio in seven starts at Oracle Park this season. 



  • 0-7 in the last seven games overall  
  • 2-6 in the last eight games against the NL West 

San Francisco:

  • 5-1 in the last six games at home 
  • 8-4 in the last 12 home games against Cincinnati      

Cincinnati Reds vs. San Francisco Giants Pick 

The moneyline odds on the Giants are not attractive, but I would settle down with it because of the Giants’ shaky bullpen. Just in the last ten days, San Francisco’s relievers have been charged for a loss four times. 

Frankly, the Giants shouldn’t have any problems outlasting the slumping Reds. Mike Minor is far away from his top form, and the Reds’ bullpen is one of the worst in the majors. Cincinnati’s relievers have accounted for an awful 6.92 ERA and 5.67 FIP in the last ten days and 26 innings of work. 

Pick: Take San Francisco Giants at -220                                

The Total:

I think the bookies set the line pretty low at 7.5 runs, so give me the over on the totals. The Giants could easily destroy Mike Minor, and I would be surprised if the Reds’ bullpen doesn’t allow a few runs down the stretch. 

On the other hand, the Reds might struggle to cope with Logan Webb. They are hitting only .237/.286/.367 across their last 169 at-bats. But with the line at 7.5 runs, I have to take the over. 

Pick: Go over 7.5 runs at -120