The 2022 MLB season continues with plenty of interesting matchups on the last day of May, including the American league showdown at Rogers Centre in Toronto, so we have prepared the best White Sox vs. Blue Jays betting pick and odds. 

Chicago and Toronto start a three-game series in Canada, as they meet for the first time in 2022. The Blue Jays are -150 home favorites for Tuesday’s opener, while the White Sox sit at +135 moneyline odds with a total of 7.5 runs on BetDSI Sportsbook.  

The Chi Sox’s iffy form goes on                               

The Chicago White Sox are one of the biggest disappointments of the 2022 season. They are sitting at the second spot in the AL Central with a 23-23 record. Furthermore, the White Sox are scoring only 3.63 runs per game (27th in the MLB) while surrendering 4.61 in a return (24th). They own the third-lowest on-base percentage (.290) and the fifth-lowest slugging percentage in the majors (.356). 

The White Sox are coming off a 5-4 12-inning victory over the Cubs, splitting a two-game interleague series against their city rivals. The Chi Sox have gone 7-6 in their previous 13 games overall, scoring 50 runs on a .251/.308/.365 in the process. 

Lucas Giolito will face the Jays on Tuesday. The 27-year-old righty sports a 3-1 record, 2.63 ERA, 1.27 WHIP, and 51/15 K/BB ratio in seven starts (37.2 innings) this season. Last Wednesday, Giolito tossed six innings of a one-run ball against the red-hot Boston Red Sox and took a win.  

The Jays are swinging a hot bat                   

The Toronto Blue Jays outlasted the Los Angeles Angels 11-10 this past Sunday to sweep a four-game series at Angel Stadium in Anaheim. It was their fifth victory in a row, as the Blue Jays improved to 27-20 on the season. 

During their winning streak, the Jays have scored 35 runs on an excellent .293/.380/.503 slash line to go with seven home runs and 16 extra-base hits. On the pitching side of things, they’ve recorded a 4.00 ERA, 1.31 WHIP, and .258 batting average against. 

Kevin Gausman will toe the rubber Tuesday, aiming for his second straight win. Last Tuesday, the 31-year-old right-hander threw six scoreless innings in an 8-1 routing of the St. Louis Cardinals. He’s 4-3 with a sharp 2.25 ERA, 1.32 FIP, and 1.04 WHIP in nine starts (56 innings) in 2022. 


Chi Sox: 

  • 5-12 in the last 17 outings as underdogs 


  • 5-0 in the last five games overall 
  • 5-2 in Kevin Gausman’s last seven starts  

Chicago White Sox vs. Toronto Blue Jays Pick 

The current White Sox have nine hits in 33 at-bats against Kevin Gausman, but they also have a 79 OPS+ against the right-handed pitchers in 2022. I’m looking for Gausman to dominate this game and help his team to extend its winning streak. The White Sox have some injury problems and will miss Tim Anderson and Luis Robert, whose absence is a massive blow for Chicago’s offense. 

On the other side, Lucas Giolito will have a tall task to slow down the in-form Blue Jays lineup. The current Jays have only eight hits in 47 at-bats against Giolito, but their recent form encourages me to go with Toronto. The Blue Jays own a 107 OPS+ against the right-handed starting pitchers in 2022. 

Pick: Take Toronto Blue Jays at -150                         

The Total:

Last week was terrible for both bullpens. The White Sox recorded a 6.56 ERA, 4.21 FIP, and .382 BABIP, while the Blue Jays posted a 4.13 ERA, 4.64 FIP, and .264 BABIP. The bookies set the line low in this one only because of the starting pitchers. 

I don’t feel comfortable with 7.5-run chalk at all. Giolito and Gausman should fare well, but you never know with these two bullpens. The under is 9-5-1 in Chicago’s last 15 games overall and 9-5 in Toronto’s previous 14. 

Pick: Go under 7.5 runs at +100