The Chicago White Sox take on the Los Angeles Angels in a three-game series finale at Angel Stadium in Anaheim on Wednesday, June 29, 2022, with the first pitch at 9:38 PM ET. These two American League foes will also close down their seven-game regular-season series, so here’s the best White Sox vs. Angels betting pick.  

According to MyBookie Sportsbook, the Angels are -150 home favorites with a total of 7.5 runs, while the White Sox are listed as +130 moneyline underdogs. 

The White Sox returned to losing ways                                            

The Chicago White Sox finished the previous week with a 4-3 win to the Baltimore Orioles, stopping their four-game slide. They suffered a 4-3 loss at Angel Stadium this past Monday, while the middle game of this series has been excluded from the analysis. 

The White Sox carried a 34-38 record into Tuesday night’s battle in Anaheim. They’ve struggled mightily at the plate in the last seven days, slashing an abysmal .219/.270/.301 across 196 at-bats. Chicago has won only one of its previous six games and scored just 15 runs in the process. 

On the other side of the ball, the Chi Sox have surrendered 30 runs in that six-game stretch. Michael Kopech will toe the slab in Wednesday’s clash at Angel Stadium, and he’s been charged for a loss in two straight starts. The 26-year-old righty holds a 2-4 record in 13 starts (62.2 innings) this season to go with a firm 2.59 ERA and 1.00 WHIP. 

The Angels hope Ohtani continues to dominate         

The 36-40 Los Angeles Angels sat at the third spot in the AL West following Monday’s victory over the White Sox. They were 11 games off the AL West-leading Houston Astros and six games behind the bottom wild card in the American League. 

The Halos were searching for their third consecutive victory on Tuesday night. They’ve won seven of their previous 12 contests and showed signs of life in the playoff chase. Still, the Angels are hitting only .216/.283/.360 in the last two weeks and 464 at-bats. 

Shohei Ohtani will get the ball Wednesday and shoot for his fourth straight win. The 27-year-old righty has allowed only one run on nine hits in his previous three starts (21 innings) while punching out 25. Ohtani fanned 13 through eight frames of a two-hit ball in a 5-0 victory to the Kansas City Royals this past Wednesday. The two-way sensation holds a 6-4 record and 2.90 ERA in 12 starts (68.1 innings) in 2022.  


Chi Sox: 

  • 1-5 in the last six games overall  
  • 2-5 in the last seven games against the Angels 
  • 1-4 in Michael Kopech’s last five starts   

LA Angels:

  • 6-1 in the last seven home games against the White Sox 
  • 10-4 in the last 14 games against the AL Central 

Chicago White Sox vs. Los Angeles Angels Pick 

Shohei Ohtani has been awful in three of his 12 starts this season. In the other nine, Ohtani has owned his opponents. Shohei sits at 2.76 FIP for the season. His slider and four-seamer have a minus-14 run value combined, and Ohtani ranks in the 85th percentile in xwOBA. Hereof, I’m expecting Ohtani to torture the White Sox, who own an 86 OPS+ against the right-handed pitchers in 2022 (.241/.297/.352 triple-slash). 

On the other side, Michael Kopech will try to right the ship after posting a pedestrian 5.23 ERA and 5.50 FIP through his five starts in June. He’ll have to deal with Ohtani, too, and Shohei has eight hits, three home runs, and ten RBIs across his last 21 at-bats. 

Pick: Take Los Angeles Angels at -150                                  

The Total:

I’ve mentioned how miserable these two offenses have been recently. However, I don’t feel comfortable with a 7.5-run line. Shohei Ohtani is swinging a hot bat, while Mike Trout has six homers in his last 11 games and 41 at-bats. 

Furthermore, you never know with the Angels’ bullpen, which has a strong 2.59 ERA in the last ten days and 41.2 innings of work. The White Sox’s bullpen has tossed 32 frames in the last ten days, tallying a 3.38 ERA and 3.60 FIP. 

Pick: Go under 7.5 runs at -110