We will have a lot of excitement this Saturday, September 17, in the MLB, but this divisional matchup is very important for the visiting team, so make sure you check out the best White Sox vs. Tigers Angels betting pick and odds.

Chicago and Detroit will play the second of a three-game series at Comerica Park, and the White Sox are -155 moneyline favorites on MyBookie Sportsbook, while the total is set at 7.5 runs. These AL Central foes have faced 13 times this year, and the White Sox lead 10-3.

White Sox blasted five homers in a win over the Guardians

The Chicago White Sox split a two-game home series against the Colorado Rockies, but they beat the divisional rivals Cleveland Guardians 8-2 in a makeup game on the road. With this win, Chicago is now only two wins behind the AL Central leaders Guardians, but Cleveland does have two games in hand.

The White Sox hit five home runs; all five from different batters. Gavin Sheets, Andrew Vaughn, Yoan Moncada, Yasmani Grandal, and Elvis Andrus all homered for Chicago, while Moncada and Jose Abreu combined for seven hits in this win. Lance Lynn (7-5) got a win as he surrendered two runs on six hits with six strikeouts and a walk over 6.1 innings of work.

Johnny Cueto (7-8) will get on the mound for the 22nd time this year when he meets Detroit on Saturday. The 36-year-old right-hander owns a rock-solid 3.09 ERA, 1.20 WHIP, and 88/31 K/BB ratio in 139.2 innings.

Tigers were swept by the Astros at home

The Detroit Tigers scored just four runs over a three-game home series against the Houston Astros and lost all three along the way. Detroit will most probably end the season at the bottom of the AL Central, while it wouldn’t be surprising to see them in the last pace of the entire AL. They are two wins above the Oakland Athletics at the moment.

Not only that the Tigers were swept by the Astros in this series, but Houston also won all seven season duels against Detroit. Javier Baez homered in Game 3 but that wasn’t enough to avoid a 2-1 defeat. Joey Wentz dropped to a 1-2 record after allowing two runs on four hits with five strikeouts and a walk in 4.0 innings.

Eduardo Rodriguez (3-5) is getting his 14th start of the year when he takes on Chicago on Saturday. The 29-year-old left-hander has a 4.50 ERA, 1.39 WHIP, and 52/26 K/BB ratio across 66.0 innings of work.



  • 5-1 in the last six road games
  • 5-1 in the last six vs. American League Central rivals
  • 6-2 in the last eight overall


  • 7-19 in the last 26 home games
  • 7-21 in the last 28 home games vs. a right-handed starter
  • 7-23 in the last 30 vs. American League Central opponents

Chicago White Sox vs. Detroit Tigers Pick

Eduardo Rodriguez didn’t enjoy his lone start against the White Sox this season. He registered a 6.75 ERA in 4.0 innings, and given how Chicago is batting against southpaws, it’s hard to expect a better display from a former Red Sox pitcher. Johnny Cueto, on the other hand, dominated in his start against Detroit as he pitched for eight scoreless innings in a win. Chicago is .283 with 5.16 runs per nine innings against lefties, while Detroit is only .215 with 3.06 runs against righties. The White Sox need this win so badly, and I am backing them to get it. 

Pick: Take the White Sox to win (-155)

The Total

After a couple of strong starts, Cueto struggles in his previous and I am backing him to return to his best on Saturday and log a quality start. Rodriguez allowed 13 runs in his last three starts, and only because of his poor form, I am going with Over in this one. Chicago, who is batting very well against left-handers, will not miss the opportunity to hit Eduardo hard, so don’t be surprised if the visitors score 5+ runs off of Rodriguez. Over is 5-2-1 in the White Sox’s last eight overall, while Over is 11-4-3 in the Tigers’ previous 18 overall.

Pick: Go Over 7.5 runs (-110)