The Baltimore Orioles meet the Chicago White Sox for a four-game American League series at Guaranteed Rate Field in Chicago, so we bring you the best O’s vs. White Sox betting pick for the opening clash set for Thursday, June 23, 2022, with the first pitch at 8:10 PM ET.  

Baltimore and Chicago lock horns for the first time this season. The White Sox are undefeated in eight straight contests against the Orioles and open as -160 home favorites for Thursday’s game. Baltimore sits at +135 moneyline odds with a total of 9.0 runs on MyBookie Sportsbook

The Orioles hope they can finally beat the White Sox                                      

Wednesday night games have been excluded from this preview, and the 30-39 Baltimore Orioles were closing down their two-game interleague set versus the Washington Nationals. Back on Tuesday, they lost 3-0 to the Nats, failing to score for the first time since the last day of May when the O’s suffered a heavy 10-0 home defeat to the Seattle Mariners. 

Baltimore has gone 9-9 through its first 18 outings in June. The Orioles have scored 88 runs on a .224/.294/.421 slash line in that 18-game stretch while posting a 4.61 ERA and 1.43 WHIP. 

Dean Kremer will toe the slab Thursday in Chicago. The 26-year-old right-hander is 1-1 with a 2.35 ERA and 1.17 WHIP in three starts (15.1 innings) this season. Last Friday, Kremer tossed six scoreless innings in a no-decision against the Tampa Bay Rays, and the Orioles eventually won 1-0. 

The White Sox need another strong outing from Johnny Cueto     

At the time of writing, the 33-33 Chicago White Sox were trailing 9-2 in the closer of a three-game home series against the Toronto Blue Jays. Lucas Giolito was obliterated for seven earned runs on 11 hits, as the White Sox’s pitching staff continues to struggle. 

Chicago outlasted Toronto 8-7 in Monday’s opener and 7-6 in 12 innings in Tuesday’s middle game. The White Sox have registered a 4.71 ERA in the last couple of weeks, and their starting rotation sits at 3.99 ERA and 1.36 WHIP for the season. 

Johnny Cueto will get the nod Thursday against the Orioles. He’s 1-3 with a 2.95 ERA, 3.64 FIP, 1.10 WHIP, and 33/11 K/BB ratio in six starts and one relief appearance (42.2 frames) this season. The veteran righty was terrific last Saturday, throwing seven scoreless innings in a 7-0 thrashing of the Houston Astros. 



  • 0-8 in the last eight games against the White Sox 

Chi Sox:

  • 6-3 in the last nine games overall     

Baltimore Orioles vs. Chicago White Sox Pick 

The current O’s have never seen Johnny Cueto before, and I don’t trust Dean Kremer, so give me the White Sox at the moneyline odds. Kremer holds a 6.06 ERA in 20 major-league starts, while the White Sox are rapidly improving at the dish following an ice-cold start to the season. 

Chicago is slashing .295/.352/.433 in June and .300/.352/.419 with four home runs across 217 at-bats in the last seven days. Tim Anderson (.355 BA, 155 OPS+) has recovered from a groin injury, while Andrew Vaughn has 28 hits and .963 OPS in his last 16 games and 70 at-bats.  

Pick: Take Chicago White Sox at -160                            

The Total:

The Orioles are slashing a miserable .218/.264/.321 over their previous five games. They’ve been unpredictable all season, and guys like Ryan Mountcastle (125 OPS+), Austin Hays (125 OPS+), and Trey Mancini (124 OPS+) can certainly hit the ball. 

Interestingly, the O’s have an 84 OPS+ at home and 97 OPS+ on the road. Their bullpen has recorded a 4.08 ERA and .324 BABIP in the last ten days, while the White Sox’s relievers have posted a 3.86 ERA and .250 BABIP in that span. I lean toward the under, but Chicago to win is my best Orioles vs. White Sox betting pick for Thursday night. 

Pick: Go under 9.0 runs at -115