We have four NFL games on Sunday night, October 2, and one of them is this Week 4 NFC clash in Charlotte, so make sure you don’t miss out on the best Cardinals vs. Panthers betting pick and odds.

Both Arizona and Carolina will be looking to improve to a 2-2 record when they face at Bank of America Stadium. The Panthers are slight 1-point favorites on MyBookie Sportsbook, while the total is set at 42.5 points. These NFC rivals have met once in 2021, and the Panthers won that game 34-10 in Arizona.

Cardinals were kept touchdown-less in a loss to the Rams

For the first time this season, the Arizona Cardinals failed to score a single touchdown in a game as they lost to the Los Angeles Rams 20-12 at home. Arizona did total 365 yards opposite the Rams’ 339 and had 23 first downs, eight more than the visitors, but Los Angeles managed to keep them out of the end zone, so the Cards had to settle with four field goals.

Matt Prater converted all four of his FG attempts – the longest from 49 yards. Kyler Murray completed 37 of 58 passes for 314 yards, 14 of which (passes) went to Marquise Brown, who finished the tilt with a game-high 140 yards. Greg Dortch chipped in 80 yards on nine receptions, while the run offense was modest with 71 yards on 21 rushes. On defense, Budda Baker and Jalen Thompson combined for 15 tackles.

WR A.J. Green departed the last game with a left knee bone bruise, and it is unlikely that he will play against the Panthers on Sunday. WR Rondale Moore (hamstring), OL Justin Pugh (elbow), and T Rashard Lawrence (hand) are questionable to feature on Sunday.

Panthers beat the Saints for the first win of the season

The Carolina Panthers secured their first victory of the NFL campaign as they beat the divisional foes, New Orleans, 22-14 at home. Carolina had a 13-0 lead after three quarters and a 15-point lead midway through the fourth. It was a great defensive display from the Panthers, who forced three turnovers and scored from one of them while committing none on the other end.

New Orleans did dominate total yards (426-293) and had 19 first downs opposite Carolina’s 12, but the home team’s defense prevailed. Marquis Haynes Sr. opened the scoring with a 44-yard fumble return, while Laviska Shenault Jr. scored the lone offensive TD for the Panthers after catching a 67-yard pass from Baker Mayfield. Shenault Jr. led the team with 90 receiving yards on just two receptions, while Christian McCaffrey led all the runners with 108 yards on 25 carries. Baker Mayfield completed 12 of 25 passes for 170 yards and a TD. Jeremy Chinn totaled eight tackles and added a sack in the win.

QB Sam Darnold (ankle) and WR Andre Roberts (knee) are out indefinitely and will not play against Arizona on Sunday.



  • 1-4 ATS in the last five games overall
  • 1-5 ATS in the last six vs. NFC rivals


  • 8-3 ATS in the last 11 games in Week 4

Arizona Cardinals vs. Carolina Panthers Pick  

After losing A.J. Green to a knee injury, and with DeAndre Hopkins already out due to suspension, Arizona will have even fewer options through the air, so the Panthers’ defenders will be all over Marquise Brown and Zach Ertz. I was impressed by the way Carolina’s D played against New Orleans and I am backing them to display another strong showing on Sunday. CMC will likely have 100+ scrimmage yards against the defense that has been one of the worst in the NFL (29.0 points allowed per game). Arizona allows the third-most passing yards (281.0), so it will be a chance for Mayfield to finally have a 250+ yard game for the first time in Carolina’s uniform.

Pick: Take the Panthers at -1 (-110)

The Total

Arizona scored 12 points and failed to register a touchdown last week, and I wouldn’t be surprised if the Cards fail to find the end zone in this one as well. It’s going to be hard for them to move the chains, especially through the air, so I expect James Conner and Kyler Murray to run the ball often. Carolina also prefers run offense over the pass, which is evident given they are 31st in the NFL with 161.3 passing yards per contest. Under is 6-2 in the Cardinals’ last eight games overall; Under is 16-5 in Arizona’s previous 21 road games, while Under is 4-1 in the Panthers’ last five vs. NFC rivals.

Pick: Go Under 42.5 points (-110)