On May 1, CBSSports.com reported ODU would join C-USA along with North Texas, Florida International, Louisiana Tech, Texas San Antonio and Charlotte.
The school will hold a 2:30 p.m. press conference on campus.
The addition of ODU will give C-USA 14 members in 2013 and ultimately the league is expected to split into two divisions: East - East Carolina, FIU, Marshall, Southern Mississippi, UAB, Charlotte and ODU; West - Louisiana Tech, North Texas, Rice, Texas San Antonio, Tulane, Tulsa and UTEP.
C-USA was forced to seek new members after Houston, SMU, UCF and Memphis announced they were leaving for the Big East in 2013. By maintaining at least 12 football members, C-USA will continue to hold its football championship game.
C-USA originally was going to merge with the Mountain West into one league, but there were too many legal obstacles and that will no longer happen, sources said. Instead, C-USA increased to 14 members and the Mountain West increased to 10 members by adding Utah State and San Jose State in 2013.
ODU is the latest school to leave the Colonial Athletic Association along with VCU, which will join the Atlantic 10 this fall, and Georgia State, which is headed to the Sun Belt. CAA football member UMass left last season for the MAC.
To help offset its losses, sources said the Colonial may pursue Davidson and Charleston.