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Michael Crabtree inflicted damage on the Arizona secondary, getting 172 receiving yards as San Francisco defeated the Cardinals 27-13 at Candlestick Park.
The 49ers earned a straight-up victory but suffered an ATS defeat in failing to cover the 16-point spread. Over-Under bettors who played OVER the total of 38.5 were rewarded with a winning wager.
Colin Kaepernick completed 16 of 28 pass attempts for 276 yards and 2 TDs for the 49ers in the win. He did not throw an interception in the game.
William Powell rushed for 52 yards for Arizona, while Brian Hoyer added 6 yards. Brian Hoyer threw for 225 yards for the Cardinals, while receivers Michael Floyd and Andre Roberts had 166 and 18 yards respectively.
San Francisco outgained Arizona 407-262 yards in the game, while the battle of first downs was won 20-11 by the 49ers.
San Francisco led the time of possession tally, as the game finished as a 36:03/23:57 split in that important category.